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Evidence is increasing that all addiction without exception is related to difficulty with the brain's reward center, especially the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, plus nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both when they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with fat loss and the those who go through it one should err to the side of caution and let the FDA do its job and demand some research be done so your public is aware of the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies come in business to make money and that they would say anything to keep people on his or her medications.

Researchers discovered that participants taking this drug to get a year, dropped excess weight within 4 weeks and have kept the weight off through the 56 weeks in the study. Contrave is a combination of the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs that are made up of several active ingredient, which can make them far better and safer.

Combo-pilling could be the newest fad or in addition to this the newest in the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that by right now there are no long term prescription weight loss supplements that have been authorized by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug may also raise hypertension and heartrate, and mustn't be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heartbeat and must not used in patients with uncontrolled high hypertension, along with by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients having a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients towards the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.


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